LYWD480 vial lyophilized drug residual oxygen detection integrated machine

Mainly engaged in the research and development of ceramic new material valves, with metal valves (gate valves, globe valves, ball valves, butterfly valves) as a secondary business. Ceramic valves have been successfully applied in many new energy battery material plants, thermal power plants, nuclear power plants, chemical plants, steel plants, coal chemical industry, polysilicon and other industries, and have been listed as special-purpose products, contributing to energy conservation and environmental protection for enterprises and society.

Main Use

Mainly used for detecting surface foreign matter, appearance defects, and filling volume of molded or controlled vials of lyophilized powder, as well as gas seal detection.

Working Principle

The inspection of pharmaceuticals is divided into two parts: lyophilized agent lamp inspection and residual oxygen content detection. The detection principles are as follows:

Lyophilized agent lamp inspection: Machine vision principle is adopted. After the vial to be inspected enters the large turntable via the in-bottle dial wheel, it rotates at a uniform speed for more than one revolution; at the same time, multiple frames of images at different angles are collected by a high-speed camera, and the images are transmitted to a distributed industrial computer; the computer detection program analyzes and judges whether the inspected medicine is qualified, and automatically separates the qualified products from the unqualified products from the production line.

Residual oxygen content detection: Laser spectroscopy analysis principle is adopted. The large turntable is equipped with a semiconductor laser detection system, whose wavelength is coordinated and matched with the absorption wavelength of oxygen. When the laser passes through the vial to be inspected, the laser absorber set at the other end of the bottle collects the oxygen absorption linearity for analysis to determine whether the vial is qualified, and automatically separates the unqualified products.

Workflow

The samples to be inspected, conveyed by the conveyor belt, are separated by the auger after entering the in-bottle dial wheel, detection turntable, out-bottle transmission dial wheel, and other inspection workstations of the equipment for online inspection. According to the real-time inspection results, the bottle separation dial wheel controls its entry into the corresponding loading tray.

The equipment has a total of 7 inspection workstations set on the in-bottle dial wheel, detection turntable, and out-bottle transmission dial wheel; the overall process flow and workstation distribution of the equipment are shown in Figure 1:

Main Technical Parameters

Applicable range: 2～30mL lyophilized powder injection in vials

Detection speed: 480 vials/minute (maximum)

Electrical capacity: 8 kW, 380(1±5%)V, three-phase AC, 50 Hz

Worktable height: 900mm

External dimensions: 3020×1910×2020 (length×width×height)

Net weight: 2600kg

Main Inspection Items

Surface foreign matter detection, appearance defect detection, and gas seal detection; each part corresponds to one or more inspection workstations; the specific inspection items and distribution areas on the bottle body for each workstation are shown in Figure 2:

The equipment is configured with a high-frequency optical path switching system. The upper surface foreign matter detection workstation, side foreign matter detection workstation, and filling volume detection workstation are all equipped with two different light source schemes. A single workstation alternately collects bottle body imaging under two different lighting environments through a high-speed camera, which can improve the detection rate of foreign matter and cracks.

Main Features

• This equipment is independently developed and innovatively combines lyophilized agent lamp inspection technology with residual oxygen content detection technology to provide a single-machine solution for visual defects and airtightness detection of lyophilized powder in vials; at the same time, this equipment also has the following advantages:
• Integrates computer vision detection and laser spectroscopy analysis, adopting a full-servo, multi-workstation design.
• High and adjustable detection accuracy: This machine uses a high-resolution industrial camera, with detection accuracy higher than manual lamp inspection; the detection accuracy has been quantified, and users can adjust it freely according to their needs.
• High-speed industrial cameras are used for detection. The lamp inspection system is equipped with 6 visual inspection workstations, collecting 10 sets of independent detection images; the single camera of the tracking workstation collects no less than 16 images, and a total of 98 detection images are collected for each bottle.
• Full servo control: The whole machine adopts full servo motor drive, compact structure, stable transmission, and can effectively reduce bottle breakage during mechanical transmission.
• Flexible detection: All specification parts of the equipment adopt pinhole design, and the large turntable adopts lifting design, making specification replacement simple and quick.
• Audit trail: The software has 3-4 levels of user permissions, and the operation permissions of different users can be customized; all user operations, parameter modifications, and production data can be traced.